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16  Logistic regression

Learning objectives

• Be able to formulate, fit, and interpret logistic regression models appropriate for binary data using R and JAGS
• Be able to compare models and evaluate model fit
• Be able to visualize models using effect plots
• Be able to describe statistical models and their assumptions using equations and text and match parameters in these equations to estimates in R output

16.1 R packages

We begin by loading a few packages upfront:

library(knitr) # for chunk options
library(kableExtra) # for tables
options(kableExtra.html.bsTable = T) 
library(patchwork) # for multi-panel plots
library(ggplot2) # for plotting
library(dplyr) # for data wrangling 
library(car) # for residual plots
library(R2jags) # for fitting models using JAGS
library(MCMCvis) # for visualizing MCMC output
library(modelsummary) # for summarizing models
library(MASS) # for generating multivariate random normal variables
library(ggeffects) # for summarizing fitted models 
library(effects) # for summarizing fitted models 
library(performance) # for residual plots
library(ggthemes) # for colorblind pallete 

In addition, we will use data and functions from the following packages:

• SightabilityModel for the moose sightability data
• sos package to search for functions to accomplish specific tasks
• ResourceSelection for the hoslem.test function
• LaplacesDemon for student-t distribution
• glmx for the BeetleMortality data set
• Data4Ecologists for the wells data set
• logistf for fitting a penalized likelihood version of a logistic regression model

16.2 Introduction to logistic regression

Often, we are interested in understanding or predicting binary response variables (i.e., variables that can take on only 1 of two values, Yes/No, Alive/Dead, Infected/Not-infected). Logistic regression is used to relate a binary response variable, \(Y_i\) , to a set of explanatory variables, \(X_i = (X_{i,1}, X_{i,2}, \ldots, X_{i,p})\). The model assumes \(Y_i\) follows a Bernoulli distribution with probability of success, \(P(Y_i = 1) = p_i\), that depends on predictors, \(X_i\), via the following set of equations:

\[Y_i | X_i \sim \text{Bernoulli}(p_i)\]

\[\log\left(\frac{p_i}{1-p_i}\right) = \text{logit}(p_i) = \beta_0 + \beta_1 X_{1,i}+ \ldots \beta_p X_{p,i}\]

The quantity \(\Large\frac{p}{1-p}\) is referred to as the odds of success, and the link function, \(\log \Big(\frac{p}{1-p}\Big)\), is referred to as logit function. Thus, we can describe our model in the following ways:

• We are modeling \(\log \Big(\frac{p}{1-p}\Big)\) as a linear function of \(X_1, \dots, X_p\).
• We are modeling the logit of \(p\) as a linear function of \(X_1, \dots, X_p\).
• We are modeling the log odds of success (defined as \(Y_i = 1\)) as a linear function of \(X_1, \dots, X_p\).

To determine \(E[Y_i|X_i] = p_i\), we need to apply the inverse-logit transformation:

\[p_i = g^{-1}(\beta_0 + \beta_1X_{1,i}+\ldots \beta_pX_{p,i}) = \frac{\exp(\beta_0 + \beta_1X_{1,i}+\ldots \beta_pX_{p,i})}{1+\exp(\beta_0 + \beta_1X_{1,i}+\ldots \beta_pX_{p,i})}.\]

As the linear predictor, \(\log \Big(\frac{p}{1-p}\Big) = \normalsize \beta_0 + \beta_1X_{1,i}+\ldots \beta_pX_{p,i}\), ranges between \(-\infty\) and \(\infty\), the odds = \(\exp\Big(\frac{p}{1-p}\Big)\) ranges between 0 and \(\infty\), and \(p\) is constrained to be between 0 and 1 (Table 16.1).

Table 16.1: Relationship between probability (p), odds, and log odds.

log odds \(= \log\Big(\frac{p}{1-p}\Big)\)	-6.907	-1.386	0.0	1.386	6.907
odds \(= \frac{p}{1-p}\)	0.001	0.250	1.0	4.000	999.000
p	0.001	0.200	0.5	0.800	0.999

We can gain further insights into the model by plotting \(p_i\) as a function of \(X_i\) for a logistic regression model with a single continuous predictor and associated intercept and slope parameters, \(\beta_0\) and \(\beta_1\), respectively (Figure 16.1). The sign of \(\beta_1\) determines whether \(p\) increases or decreases as \(X_i\) increases, and its magnitude controls how quickly \(p_i\) transitions from 0 to 1

Figure 16.1: Probability of success for different slope coefficients in a logistic regression model with a single continuous predictor and \(\beta_0 = 0\). The intercept \(\beta_0\) controls the height of the curve when \(X_i=0\). For the curves depicted in Figure 16.1, \(\beta_0 = 0\). Thus, \(E[Y_i |X_i=0] = \frac{exp(\beta_0)}{1+exp(\beta_0)} = 1/2\).

16.3 Parameter Interpretation: Application to moose detection data

In Chapter 11, we considered data collected by the Minnesota Department of Natural Resoureces (MN DNR) to estimate the probability of detecting a moose when flying in a helicopter (Giudice, Fieberg, and Lenarz 2012). The probability of detecting a moose will depend on where the moose is located (e.g., the amount of cover that shields the moose from view, termed visual obstruction (or VOC); Figure 16.2). If we model the probability of detection as a function of VOC, we can then adjust counts of observed animals in future surveys that also record this information, providing a formal method for estimating moose abundance that accounts for imperfect detection (Fieberg 2012; Fieberg et al. 2013; ArchMiller et al. 2018). We might also want to consider whether detection probabilities vary by observer (a categorical variable) or whether detection probabilities varied among the four years of data collection.

Figure 16.2: Observations of moose in Minnesota with a circular field of view used to measure the degree of visual obstruction. Photos by Mike Schrage, Fond du Lac Resource Management Division.

Let’s read in a data set with the observations recording whether each moose was observed or not (observed) along with potential covariates for modeling the probability of detection. The data are contained in the SightabilityModel package (Fieberg 2012) and can be accessed using:

library(SightabilityModel)
data(exp.m)
str(exp.m)

'data.frame':   124 obs. of  4 variables:
 $ year    : int  2005 2005 2005 2005 2005 2005 2005 2005 2005 2005 ...
 $ observed: int  1 1 0 0 0 0 1 1 1 1 ...
 $ voc     : int  20 85 80 75 70 85 20 10 10 70 ...
 $ grpsize : int  4 2 1 1 1 1 1 2 2 2 ...

The data set in this package contains a small subset of the variables that could be used to model detection probabilities (see Giudice, Fieberg, and Lenarz 2012 for a discussion regarding how these were chosen). We will focus on the relationship between detection and visual obstruction measurements using the variables observed and voc, respectively. Note that the variable observed is binary:

\[observed_{i} = \left\{ \begin{array}{ll} 1 & \mbox{if the radiocollared moose was detected}\\ 0 & \mbox{if the radiocollared moose was not detected} \end{array} \right.\]

In Figure 16.3, we use a smoother to visualize overall trends in detection probabilities relative to voc. As expected, we see that detection probabilities decrease as the amount of screening cover increases. We could fit a linear regression model to the data. However, this approach would fail to capture several of the characteristics of the data:

• Detection probabilities must necessarily fall between 0 and 1.
• The observations do not have have constant variance (recall the variance of a Bernoulli random variable = \(p(1-p)\), which will be at its highest value when \(p=0.5\)).

ggplot(exp.m, aes(voc,observed))+theme_bw()+
    geom_point(position = position_jitter(w = 2, h = 0.05), size=3) +
    geom_smooth(colour="red") + xlab("Visual Obstruction") +
    ylab("Detection = 1")

Figure 16.3: Detection of moose as a function of the amount of visual obstruction within an approximate 10m radius of the moose.

Letting \(Y_i = observed_i\), and \(X_i = voc_i\), we can specify a logistic regression model for the moose data using the following set of equations:

\[Y_i | X_i \sim Bernoulli(p_i)\]

\[logit(p_i) = \log\left(\frac{p_i}{1-p_i}\right) = \beta_0 + \beta_1 voc_i\]

We can fit this model using glm with family =binomial().

mod1 <- glm(observed ~ voc, data = exp.m, family = binomial())

By default, glm will use a logit link when specifying family=binomial(), but other links are possible. Similar to other regression models we’ve seen, we can use the summary function to view the estimated coefficients, their standard errors, and explore hypothesis tests for whether the coefficients are 0 (versus an alternative that they are not 0):

summary(mod1)

Call:
glm(formula = observed ~ voc, family = binomial(), data = exp.m)

Coefficients:
             Estimate Std. Error z value Pr(>|z|)    
(Intercept)  1.759933   0.460137   3.825 0.000131 ***
voc         -0.034792   0.007753  -4.487 7.21e-06 ***
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for binomial family taken to be 1)

    Null deviance: 171.61  on 123  degrees of freedom
Residual deviance: 147.38  on 122  degrees of freedom
AIC: 151.38

Number of Fisher Scoring iterations: 4

We see that the log-odds of detection decreases by -0.035 as we increase voc by 1 unit (i.e., for every increase of 1% visual obstruction). Alternatively, it is common to report effect sizes in terms of a change in odds. The odds of detection is given by:

\[\frac{p_i}{1-p_i}= \exp(\beta_0+\beta_1voc_i) = e^{\beta_0}e^{\beta_1voc_i}\]

Thus, if we increase voc by 1 unit, we increase the odds by \(e^{\beta_1}\). To calculate a confidence interval for the change in odds associated with a 1 unit increase in a predictor variable, it is common to calculate a confidence interval for \(\beta_1\) and then exponentiate the limits (similar to what we saw for Poisson regression). Again, we can rely on large sample theory for Maximum Likelihood estimators, \(\hat{\beta}\sim N(\beta, I^{-1}(\beta))\), and the output from the summary of the glm model to calculate a 95% confidence interval for \(\beta_1\) and also for the change in odds (Table 16.2).

beta1 <- coef(mod1)[2]
SEbeta1 <- sqrt(diag(vcov(mod1)))[2]
oddsr <- exp(beta1)
CI_beta <- beta1 + c(-1.96, 1.96)*SEbeta1
CI_odds <- exp(CI_beta)
estdata <- data.frame(beta1 = beta1, SEbeta1 = SEbeta1,  
           LCL_beta = CI_beta[1], UCL_beta = CI_beta[2], oddsratio  = oddsr,
           LCL_odds = CI_odds[1], UCL_odds = CI_odds[2])
colnames(estdata) <- c("$\\widehat{\\beta}_1$", "$SE(\\widehat{\\beta}_1)$", 
                             "Lower 95\\% CL", "Upper 95\\% CL", "$\\exp(\\beta_1)$",
                             "Lower 95\\% CL", "Upper 95\\% CL")
kable(round(estdata,3), booktabs = TRUE, escape = FALSE)

Table 16.2: Estimates of the effect of visual obstruction (\(\beta_1\), \(\exp(\beta_1)\), and 95% CIs) on moose detection probabilities.

	\(\widehat{\beta}_1\)	\(SE(\widehat{\beta}_1)\)	Lower 95% CL	Upper 95% CL	\(\exp(\beta_1)\)	Lower 95% CL	Upper 95% CL
voc	-0.035	0.008	-0.05	-0.02	0.966	0.951	0.981

Alternatively, we could calculate profile-likelihood based confidence intervals by inverting the likelihood ratio test (Section 10.10). Recall, profile-likelihood intervals include all values, \(\widetilde{\beta}\), for which we would not reject the null hypothesis \(H_0: \beta=\widetilde{\beta}\). In small samples, profile likelihood intervals should perform better than the Normal-based intervals, and thus, this is the default approach used by the function confint.

(ci.prof <- confint(mod1))

Waiting for profiling to be done...

                  2.5 %      97.5 %
(Intercept)  0.89794673  2.71375978
voc         -0.05082098 -0.02025314

(exp(ci.prof)) 

                2.5 %     97.5 %
(Intercept) 2.4545581 15.0858887
voc         0.9504488  0.9799506

The Normal-based and profile-likelihood confidence intervals are similar in this case. If confidence limits for \(\beta\) do not include 0 or confidence limits for \(\exp(\beta)\) do not include 1, then we might say that the results are statistically significant at the \(\alpha = 0.05\) level.

We can also use tab_model in the sjPlot library or the modelsummary function in the modelsummary package to calculate a table of effect sizes for our model (Table 16.3). By default, tab_model reports effect sizes in terms of odds, labeled Odds Ratios. We can can also calculate odds ratios by adding the argument exponentiate = TRUE when calling the modelsummary function (Table 16.3).

modelsummary(list("Logistic regression" = mod1),
             exponentiate = TRUE, gof_omit = ".*", estimate  = "{estimate} ({std.error})", 
             statistic=NULL,  
             coef_omit = "SD") 

Table 16.3: Odds ratios (SE) from the logistic regression model fit to the moose detection data.

	Logistic regression
(Intercept)	5.812 (2.674)
voc	0.966 (0.007)

To understand why \(\exp(\hat{\beta})\) is referred to as an odds ratio, consider the ratio of odds for two observations that differ only in voc with \(voc_2 = voc_1+1\). The ratio of odds for observation 2 relative to observation 1 is given by:

\[\frac{\frac{p_2}{1-p_2}}{\frac{p_1}{1-p_1}} = \frac{e^{\beta_0}e^{\beta_1voc_2}}{e^{\beta_0}e^{\beta_1voc_1}} = \frac{e^{\beta_1(voc_1+1)}}{e^{\beta_1voc_1}}= e^{\beta_1}\]

What about the intercept? The intercept gives the log-odds of detection when voc = 0 (i.e., when moose are completely in the open). We can also use the plogis function in R to calculate the inverse-logit transform, \(g^{-1}(\beta_0) = \frac{exp(\beta_0)}{1+exp(\beta_0)}\), which provides an estimate of the probability of success when all covariates are equal to 0 (or when all covariates are set to their means if we use centered and scaled predictors):

plogis(coef(mod1)[1]) 

(Intercept) 
  0.8532013 

Thus, the model predicts there is an 85% chance of detecting a moose when it is completely in the open (i.e., when voc = 0).

Lastly, we can visualize the model using ggplot, here with stat_smooth used to specify our regression model (Figure 16.4).

ggplot(exp.m, aes(voc,observed)) + theme_bw() + 
    geom_point(position = position_jitter(w = 2, h = 0.05), size=3) +
    xlab("Visual Obstruction") + 
    stat_smooth(method="glm", method.args = list(family = "binomial") )+
    ylab("Detection (Yes = 1)") 

Figure 16.4: Fitted logistic regression model relating detection probabilities to the amount of visual obstruction.

16.3.1 Model with continuous and categorical variables

Let’s now consider a second model, where we also include the year of the observation as a predictor. Rather than model a smooth trend in detection probabilities over time, we will use the as.factor function to create a categorical variable to represent the different years.

exp.m$year <- as.factor(exp.m$year)
mod2 <- glm(observed ~ voc + year, data = exp.m, family = binomial())
summary(mod2)

Call:
glm(formula = observed ~ voc + year, family = binomial(), data = exp.m)

Coefficients:
             Estimate Std. Error z value Pr(>|z|)    
(Intercept)  2.453203   0.622248   3.942 8.06e-05 ***
voc         -0.037391   0.008199  -4.560 5.11e-06 ***
year2006    -0.453862   0.516567  -0.879   0.3796    
year2007    -1.111884   0.508269  -2.188   0.0287 *  
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for binomial family taken to be 1)

    Null deviance: 171.61  on 123  degrees of freedom
Residual deviance: 142.23  on 120  degrees of freedom
AIC: 150.23

Number of Fisher Scoring iterations: 4

Again, R uses reference coding by default. This provides another opportunity to revisit design matrices from Chapter 3 as well as further test our ability to interpret the regression coefficients when we include multiple predictor variables.

Think-Pair-Share: How can we interpret the coefficients in our model with year and voc?

Since we did not include an interaction between voc and year, we have assumed the effect of voc is the same in all years. We can interpret the effect of voc in the same way as in Section 16.3, except we must now tack on the phrase while holding year constant. I.e., the log odds of detection changes by 0.037 and the odds of detection by 0.96 for every 1 unit increase in voc while holding year constant.

What about the three coefficients associated with the year variables that R created? These coefficients provide estimates of differences in the log odds of detection between each listed year and 2005 (the reference level), while holding voc constant. And, if we exponentiate these coefficients, we get ratios of odds (i.e., odds ratios) between each year and 2005 (Table 16.4), while holding voc constant.

Table 16.4: Odds ratios = \(\exp(\beta)\) (SE) from the fitted logistic regression model with voc and year.

	Logistic regression
(Intercept)	11.626 (7.234)
voc	0.963 (0.008)
year2006	0.635 (0.328)
year2007	0.329 (0.167)

Thus, for example, we can conclude that the odds of detection were 1/0.635 = 1.57 times higher in 2005 than 2006 if we hold voc constant.

16.3.2 Interaction model

What if we were to include an interaction between voc and year?

mod3 <- glm(observed ~ voc * year, data = exp.m, family = binomial())
summary(mod3)

Call:
glm(formula = observed ~ voc * year, family = binomial(), data = exp.m)

Coefficients:
             Estimate Std. Error z value Pr(>|z|)  
(Intercept)   1.53466    0.83338   1.841   0.0656 .
voc          -0.02224    0.01287  -1.728   0.0839 .
year2006      0.35841    1.20786   0.297   0.7667  
year2007      0.55335    1.13559   0.487   0.6261  
voc:year2006 -0.01310    0.02002  -0.655   0.5127  
voc:year2007 -0.03151    0.01983  -1.589   0.1121  
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for binomial family taken to be 1)

    Null deviance: 171.61  on 123  degrees of freedom
Residual deviance: 139.60  on 118  degrees of freedom
AIC: 151.6

Number of Fisher Scoring iterations: 4

Think-Pair-Share: How can we interpret the coefficients in the above model?

The year2006 and year2007 terms provide estimates of differences in intercepts between each listed year and the reference level (2005 in this case) and the voc:year2006 and voc:year2007 terms provide estimates of differences in slopes between each listed year and the reference level year. If this is not clear, it would help to review Chapter 3. You might also consider trying to write out the design matrix for a few observations in the data set that come from different years. You could then check your understanding using the model.matrix function. Try writing out the design matrix for the following observations:

exp.m[c(1,37,53,74), c("voc", "year")]

    voc year
37   20 2005
73   10 2007
89   60 2006
110  85 2007

Check your answer by typing:

model.matrix(mod3)[c(1,37,53,74),]

16.4 Evaluating assumptions and fit

16.4.1 Residual plots

As discussed in Section 15.4.1, there are multiple types of residuals (standard, Pearson, deviance) that we might consider using to evaluate model fit. Below, we use the residualPlots function in the car library to create plots of Pearson residuals versus model predictors and versus fitted values (Figure 16.5).

 residualPlot(mod1)

Figure 16.5: Residual plots for the logistic regression model fit to data from Moose in Minnesota.

The residuals for binary data always look weird since \(Y_i\) can only take on the values of 0 and 1. Thus, it is important to focus on the smooth line to see if there is any patterning. Alternatively, it can be beneficial to create binned residual plots by “dividing the data into categories (bins) based on their fitted values, and then plotting the average residual versus the average fitted value for each bin.” (Gelman and Hill 2006). The binned_residual function in the performance package will do this for us (Figure 16.6). It also provides error bounds and colors binned residuals that fall outside these bounds to help easily visualize whether the model provides a reasonable fit to the data.

binplot<-binned_residuals(mod1)
plot(binplot)

Figure 16.6: Binned residual plot for the logistic regression model containing only voc. The model looks OK, except that it is underpredicting those observations that have the highest probabilities of detection; these are the observations with the smallest values of voc.

16.4.2 Goodness-of-fit test

We can easily adapt the general approach for testing goodness-of-fit from Section 13.4 and Section 15.4.5 to logistic regression models. Again, we will consider the sum of Pearson residuals as our goodness-of-fit statistic:

\[\chi^2_{n-p} = \sum_{i=1}^n\frac{(Y_i-E[Y_i|X_i])^2}{Var[Y_i|X_i]}\]

For binary data analyzed using logistic regression, we have:

• \(E[Y_i|X_i] = p_i\) = \(\Large \frac{exp(\beta_0 + \beta_1x_1+\ldots \beta_kx_k)}{1+exp(\beta_0 + \beta_1x_1+\ldots \beta_kx_k)}\)
• \(Var[Y_i|X_i] =\) \(p_i(1-p_i)\)

Here, we demonstrate the approach using the simpler model containing only voc.

  nsims<-10000
  gfit.sim<-gfit.obs<-matrix(NA, nsims, 1)
  nobs<-nrow(exp.m)
  beta.hat<-mvrnorm(nsims, coef(mod1), vcov(mod1))
  xmat<-model.matrix(mod1)
  for(i in 1:nsims){
    # Form predictions using the randomly chosen betas
    ps<-plogis(xmat%*%beta.hat[i,])
    # Generate new y's
    new.y<-rbinom(nobs, size=1, prob=ps)
    # Calculate Pearson residuals
    gfit.sim[i,]<-sum((new.y-ps)^2/(ps*(1-ps)))
    gfit.obs[i,]<-sum((exp.m$observed-ps)^2/(ps*(1-ps)))
  }
  # GOF p-value
  mean(gfit.sim > gfit.obs) 

[1] 0.466

The p-value is much greater than 0.05, suggesting we do not have significant evidence to conclude that the logistic regression model with voc is inappropriate for our data.

16.4.3 Aside: alternative methods for goodness-of-fit testing

It is also common to see goodness-of-fit tests that ignore parameter uncertainty and that group observations to better meet the asymptotic \(\chi^2\) distributional assumption¹. For example, observations may be grouped by deciles of their predicted values (similar to how the binned residual plot is constructed). The observed (\(O_i\)) and expected (\(E_i\)) number of successes and failures is then calculated for each group and compared to a \(\chi^2\) distribution:

\[\chi^2 = \sum_{i=1}^{n_g}\frac{(O_i-E_i)^2}{E_i} \sim \chi^2_{g-2}, \mbox{where}\] \(g\) = number of groups.

This approach is called the Hosmer-Lemeshow test (Hosmer Jr, Lemeshow, and Sturdivant 2013). There are many different implementations of this test in various R packages. To see a listing, we could use the findFn function from the sos package. If you run the code, below, you will see that there are over 40 packages that show up.

library(sos)
findFn("hosmer lemeshow")

One such implementation is in the ResourceSelection package (Lele, Keim, and Solymos 2019).

library(ResourceSelection)
hoslem.test(exp.m$observed, fitted(mod1), g = 8)

    Hosmer and Lemeshow goodness of fit (GOF) test

data:  exp.m$observed, fitted(mod1)
X-squared = 3.2505, df = 6, p-value = 0.7768

The performance_hosmer function in the performance package (Lüdecke et al. 2021) also implements this test.

performance_hosmer(mod1)

# Hosmer-Lemeshow Goodness-of-Fit Test

  Chi-squared: 6.674
           df: 8    
      p-value: 0.572

Summary: model seems to fit well.

The p-values differ in the two implementations due to using a different number of groups (8 versus 10), which highlights a potential limitation of this test. Note, if we change g = 10 in the call to hoslem.test, we replicate the output from performance_hosmer.

16.5 Model comparisons

We can again use likelihood ratio tests to compare full and reduced models using either the drop1 function or the Anova function in the car package (Fox and Weisberg 2019). Let’s start with the model containing voc and year but not their interaction and consider whether we can simplify the model by dropping either voc or year.

drop1(mod2, test="Chisq")

Single term deletions

Model:
observed ~ voc + year
       Df Deviance    AIC     LRT  Pr(>Chi)    
<none>      142.23 150.23                      
voc     1   168.20 174.20 25.9720 3.464e-07 ***
year    2   147.38 151.38  5.1558   0.07593 .  
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

The top row of this table reports the AIC for the full model containing both voc and year. The second and third rows report AICs for reduced models in which either voc (second row) or year (third row) are dropped. The last two columns report the test-statistic and p-value associated with the likelihood ratio test comparing full and reduced models. The small p-value for the voc row suggests we should prefer the observed ~ voc + year model relative to the observed ~ year model. This again confirms that voc is an important predictor of the probability of detection. The results are less clear when comparing the observed ~ voc and observed ~ voc + year models, with a p-value of 0.07.

We can get the same set of tests using the Anova function in the car package:

Anova(mod2) 

Analysis of Deviance Table (Type II tests)

Response: observed
     LR Chisq Df Pr(>Chisq)    
voc   25.9720  1  3.464e-07 ***
year   5.1558  2    0.07593 .  
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Lastly, we could compare nested or non-nested models using the AIC function. Here we compare:

• mod1 = observed ~ voc
• mod2 = observed ~ voc + year
• mod3 = observed ~ voc * year

AIC(mod1, mod2, mod3)

     df      AIC
mod1  2 151.3824
mod2  4 150.2266
mod3  6 151.6040

The model with voc and year but not their interaction has the lowest AIC.

16.6 Effect plots: Visualizing generalized linear models

It is easy to use ggplot to visualize models containing a single continuous variable as in Figure 16.4. We can also use ggplot to easily visualize regression models that include 1 categorical and 1 continuous predictor, along with their interaction – using a single plot or a multi-panel plot (e.g., Figure 16.7).

p1<-ggplot(exp.m, aes(x=voc, y=observed, colour=year)) + theme_bw()+
   geom_point(position = position_jitter(w = 2, h = 0.05), size=3) + 
   stat_smooth(method="glm", method.args = list(family = "binomial"),
               se=FALSE) +
  scale_colour_colorblind()

p2<-ggplot(exp.m, aes(voc,observed))+ theme_bw() + 
    geom_point(position = position_jitter(w = 2, h = 0.05), size=3) +
    xlab("Visual Obstruction") + 
    stat_smooth(method="glm", method.args = list(family = "binomial"))+
    ylab("Detection = 1") +facet_wrap("year")
(plot_spacer() + p1 + plot_spacer()) / p2 

Figure 16.7: Fitted logistic regression model relating detection probabilities to the amount of visual obstruction, year, and their interaction.

What if we fit more complicated models containing multiple predictor variables? We have a few options:

1. We can create predicted values for different combinations of our explanatory variables, their standard errors, and then plot the results.
2. We can use one or more R packages to automate this process. In Section 16.6.4, we will explore the effects (Fox and Weisberg 2018) and ggeffects packages (Lüdecke 2018), which were also introduced in Section 3.14 when we discussed creating partial residual plots.

Let’s begin by creating our own plots, which will give us insights into how these latter packages work.

16.6.1 Predictions and confidence intervals

Let’s begin by considering our initial model containing only voc. We can summarize models in terms of: \(\hat{E}[Y_i|X_i] = \hat{p}_i= \hat{P}(Y_i=1 | voc_i)\) for a range of voc values (Figure 16.8). The easiest way to accomplish this is to use the predict function in R. Specifically, we can generate predictions for a range of values of voc using:

voc.p<-seq(1, 99, length = 100)
p.hat <- predict(mod1, newdata = data.frame(voc = voc.p), type = "response")

plot(voc.p, p.hat, xlab = "VOC", ylab = "Pr(detect | voc)", type = "l")

Figure 16.8: Predicted probability of detecting a moose as a function of visual obstruction (voc) only.

We could also ask the predict function to return standard errors associated with our predictions by adding the argument se.fit=TRUE. If we ask for SEs on the response scale, these standard errors will be calculated using the delta method (see Section 10.8.1). We could then use \(\hat{p}_i\pm 1.96SE\) to form confidence intervals for our plot, depicting how \(p_i\) (and our uncertainty about \(p_i\)) depends on voc. Remember, that \(p_i\) has to be between 0 and 1, and there is no guarantee that these confidence intervals will remain \(\le 1\) or \(\ge 0\). A better approach is to use predict to generate estimates on the link (i.e., logit) scale, along with standard errors on this scale. Using this information, we can then form a confidence interval for \(\text{logit}(p_i)\) and then back-transform this interval using the plogis function to get a confidence interval for \(p_i\). This approach has several advantages:

1. The sampling distribution for \(\text{logit}(\hat{p}_i) = \hat{\beta}_0 + \hat{\beta}_1X_{1,i} + \ldots \hat{\beta}_pX_{p,i}\) tends to be more Normal than the sampling distribution for \(\hat{p}_i\).

2. Confidence intervals will be guaranteed to live on the (0,1) scale. Also, note that the intervals will not be symmetric.

The code and plot below compares these two approaches (Figure 16.9):

# Predictions response scale
newdat <- data.frame(voc = seq(1, 99, length = 100))
phat <- predict(mod1, type = "resp", se.fit = T,newdata = newdat)
lcl.r <- phat$fit + 1.96 * phat$se.fit
ucl.r <- phat$fit - 1.96 * phat$se.fit

# Predictions link scale
phat2<-predict(mod1, type = "link", se.fit = T, newdata = newdat)
lcl.l <- plogis(phat2$fit + 1.96 * phat2$se.fit)
ucl.l <- plogis(phat2$fit - 1.96 * phat2$se.fit)
pe.l <- plogis(phat2$fit)

# Combine and plot
newdat <- cbind(newdat, phat = phat$fit, lcl.r, ucl.r, phat2 = phat2$fit, lcl.l, ucl.l, pe.l)
ggplot(newdat, aes(voc, phat)) + geom_line() + 
  geom_line(aes(voc, lcl.l), lty = 2, col = "blue") +
  geom_line(aes(voc, ucl.l), lty = 2, col = "blue") +
  geom_line(aes(voc, lcl.r), lty = 2, col = "red") +
  geom_line(aes(voc, ucl.r), lty = 2, col = "red") + 
  xlab("Visual Obstruction") + ylab(expression(hat(p)))

Figure 16.9: Comparison of methods for forming confidence intervals on the response scale in red versus link scale with back transformation in blue.

16.6.2 Aside: Revisiting predictions using matrix algebra

How does R and the predict function work? Here, we briefly revisit the ideas from Section 5.6 and Section 3.12. Remember, glm estimates \(\beta\) using maximum likelihood, specifically, by maximizing:

\[L(\beta; y, x) = \prod_{i=1}^{n}p_i^{y_i}(1-p_i)^{1-y_i} \mbox{ with}\]

\[p_i = \frac{e^{\beta_0 + \beta_1X_{1 ,i}+ \ldots \beta_pX_{p,i}}}{1+e^{\beta_0 + \beta_1X_{1,i} + \ldots \beta_pX_{p,i}}}\]

Also, remember, for large samples, \(\hat{\beta} \sim N(\beta, I^{-1}(\beta))\). We can use this theory to conduct hypothesis tests (see the p-values using z-statistics in the output by the summary function) and to get confidence intervals.

Let \(X\) = our design matrix, in this case consisting of 2 columns (a column of 1’s for the intercept and a second column containing the voc measurements). Again, we can use model.matrix to see what this design matrix looks like.

Let \(\beta = (\beta_0, \beta_1)\), our vector of parameters (intercept and slope).

We can calculate \(\text{logit}(\hat{p}_i|X_i)\) and its SE using matrix multiplication:

• \(\text{logit}(\hat{p}_i|X_i) = X\hat{\beta}\) (use %*% in R to perform matrix multiplication)
• Variance/covariance of \(\text{logit}(\hat{p}|X) = X(\hat{I}^{-1}(\beta))X^T\) (we access our estimate of \(I^{-1}(\beta)\) using vcov(mod1)).

The code below demonstrates that we get the same results using matrix multiplication as when using the predict function.

newdata <- data.frame(observed = 1, voc = voc.p)
xmat <- model.matrix(mod1, data = newdata)
p.hat.check <- xmat %*% coef(mod1)
p.se.check <- sqrt(diag(xmat %*% vcov(mod1) %*% t(xmat)))
# Compare predictions
summary(predict(mod1, newdata = newdata, type = "link") - p.hat.check)

       V1   
 Min.   :0  
 1st Qu.:0  
 Median :0  
 Mean   :0  
 3rd Qu.:0  
 Max.   :0  

# Compare SEs
summary(predict(mod1, newdata = newdata, type = "link", se.fit = TRUE)$se.fit - p.se.check)

      Min.    1st Qu.     Median       Mean    3rd Qu.       Max. 
-5.551e-17  5.551e-17  5.551e-17  6.634e-17  1.110e-16  1.665e-16 

16.6.3 Additive effects on logit scale \(\ne\) additive effects on probability scale

Creating and interpreting effect plots is a little trickier than it might seem due to modeling the mean on the logit scale. Let’s consider our second model:

\[Y_i|X_i \sim \text{Bernoulli}(p_i)\] \[\text{logit}(p_i) = \beta_0 + \beta_1voc_i + \beta_2I(year=2006)_i+\beta_3I(year=2007)_i\]

Here, the effects of year and voc are “additive” on the logit scale, and thus, differences in logit(\(p_i\)) between years do not depend on voc. However, the effects of voc and year are multiplicative on the odds scale and even more complicated on the \(p\) scale (see e.g., the discussion related to parameter interpretation in Section 16.3). As a result, differences in \(p_i\) between years will depend on voc and the effect of voc on \(p\) will depend on the year (even though we do not have an interaction in the model!).

To see this in action, let’s plot \(\text{logit}(p_i)\) and \(p_i\) versus voc for the different years (Figure 16.10). Note that distances between the lines for the different years are constant when we look at \(\text{logit}(p_i)\) but not when we plot \(p_i\) (the curves are closer together as \(p_i\) approaches 0 or 1). These differences result from having to back-transform from the logit to response scale.

  newdat<-expand.grid(voc=seq(0,100,5), year=unique(exp.m$year))  
  newdat$p.hats<-predict(mod2, newdat=newdat, type="response")
  newdat$logit.p.hats<-predict(mod2, newdata=newdat, type="link")
  plot.logitp<-ggplot(newdat, aes(voc, logit.p.hats, colour=year))+geom_line()+
    ylab("logit(p)")
  plot.p<-ggplot(newdat, aes(voc, p.hats, colour=year))+geom_line()+ylab("p")
  plot.logitp + plot.p 

Figure 16.10: Relationships between the amount of visual obstruction (voc) and logit(\(p\)) (left panel) and \(p\) (right panel).

16.6.4 Effect plots for complex models: Using the effects and ggpredict packages

Recall from Section 3.14.3, we can visualize the effect of predictors using effect plots formed by varying 1 predictor while holding all other predictors at a common value (e.g., the mean for continuous variables and the modal value for categorical variables). The expand.grid function, used in the creation of Figure 16.10 can be a big help here as it makes it easy to create a data set containing all combinations of multiple predictor variables. Still, creating effect plots from scratch can be a little tedious. The effects and ggeffects packages can makes this process a little easier.

16.6.4.1 Effects package

The effect function in the effects package:

• Fixes all continuous variables (other than the one of interest) at their mean values
• For categorical predictors, it averages predictions on the link scale, weighted by the proportion of observations in each category

By default, plots are constructed on the link scale, but we can add type="response" to create a plot on response scale. Examples are given in Figure 16.11 and Figure 16.12.

plot(effect("voc", mod2), type="response")
plot(effect("year", mod2), type="response")

Figure 16.11: Effect plots showing how the probability of detection varies with voc and with year using the model with voc and year.

We can add partial residuals using adding parital.residuals = TRUE to the effect function (Figure 16.12). For binary data, it is difficult to interpret the raw residuals, but this option also overlays a smooth line capturing any trend.

plot(effect("voc", mod2, partial.residuals = TRUE), type="response")

Figure 16.12: Effect plot with partial residuals added, showing how the probability of detection varies with voc using the model with voc and year.

We can also use effect and the summary functions to return numerical values (estimates and confidence intervals):

summary(effect("year", mod2))

 year effect
year
     2005      2006      2007 
0.6105102 0.4988990 0.3401946 

 Lower 95 Percent Confidence Limits
year
     2005      2006      2007 
0.4338786 0.3283351 0.2086299 

 Upper 95 Percent Confidence Limits
year
     2005      2006      2007 
0.7622325 0.6697194 0.5020875 

Alternatively, we can use the ggeffect function in the ggeffects package to format the output as a list with an associated print function.

ggeffect(mod2)

$voc
# Predicted probabilities of observed

voc | Predicted |     95% CI
----------------------------
  0 |      0.87 | 0.72, 0.94
 10 |      0.82 | 0.67, 0.91
 20 |      0.76 | 0.62, 0.86
 35 |      0.64 | 0.52, 0.74
 55 |      0.46 | 0.36, 0.56
 65 |      0.37 | 0.27, 0.47
 75 |      0.29 | 0.19, 0.41
 95 |      0.16 | 0.08, 0.29

Not all rows are shown in the output. Use `print(..., n = Inf)` to show
  all rows.

$year
# Predicted probabilities of observed

year | Predicted |     95% CI
-----------------------------
2005 |      0.61 | 0.43, 0.76
2006 |      0.50 | 0.33, 0.67
2007 |      0.34 | 0.21, 0.50


attr(,"class")
[1] "ggalleffects" "list"        
attr(,"model.name")
[1] "mod2"

There is also a plot function that we can use with the ggeffect function to visualize these effects (Figure 16.13).

p1 <- plot(ggeffect(mod2, "year"))
p2 <- plot(ggeffect(mod2, "voc"))
p1 + p2

Figure 16.13: Effect plot for the model with voc and year created using the ggeffects package.

And again, we could add partial residuals and a smooth line to our plot (Figure 16.14).

plot(ggeffect(mod2, "voc"), show_residuals = TRUE, show_residuals_line = TRUE)

Figure 16.14: Effect plot created using the ggeffects package with partial residuals overlayed.

Lastly, we can specify specific terms for which we want estimates. In this case, ggeffects will return a data.frame from which we can create our own plot using ggplot (Figure 16.15).

effects.mod2 <- ggeffect(mod2, terms = c("voc", "year"))
ggplot(effects.mod2, aes(x, predicted, col = group)) + geom_line()

Figure 16.15: Effect plot created using the ggeffects package along with ggplot.

16.6.5 Understanding effect estimates from the effects and ggeffects packages

The goal of this section is to illuminate how the estimates and confidence intervals on the response scale are formed when using the effects package or the ggeffects function in the ggeffects package. Let’s begin by considering the effects for year. These are formed by setting voc to its mean value, and estimating:

\(P(Y_i = 1 | year = year_i, voc = \overline{voc})\) for each of the years in the data set. These estimates are easy to understand and recreate using the predict function:

newdata<-data.frame(voc = rep(mean(exp.m$voc), 3), 
                    year = c("2005", "2006", "2007"))
predict(mod2, newdata = newdata, type = "resp")

        1         2         3 
0.6105102 0.4988990 0.3401946 

effect("year", mod2, type = "response")

 year effect
year
     2005      2006      2007 
0.6105102 0.4988990 0.3401946 

Now, how does the effects package estimate the effect of voc? There is no “mean or average” year since year is a categorical variable. Instead, it calculates a weighted mean of the predictions for each year on the link scale, with weights given by the proportion of observations in each category. It then back-transforms this weighted mean.

effect("voc", mod2)

 voc effect
voc
        0        20        50        70       100 
0.8684553 0.7575962 0.5044524 0.3251918 0.1356677 

# Proportion of observations in each year (will be used to form weights)
weights <- data.frame(table(exp.m$year) / nrow(exp.m))
names(weights) = c("year", "weight")
weights

  year    weight
1 2005 0.3145161
2 2006 0.2983871
3 2007 0.3870968

# New data for predictions  
newdata <- data.frame(expand.grid(year = c("2005", "2006", "2007"),
  voc = seq(0, 100, 20)))
newdata <- left_join(newdata, weights)

# Predictions on link scale    
newdata$logit.phat <- predict(mod2, newdata = newdata, type = "link")

# Weight predictions and backtransform  
newdata %>% group_by(voc) %>% dplyr::summarize(plogis(sum(logit.phat * weight)))

# A tibble: 6 × 2
    voc `plogis(sum(logit.phat * weight))`
  <dbl>                              <dbl>
1     0                              0.868
2    20                              0.758
3    40                              0.597
4    60                              0.412
5    80                              0.249
6   100                              0.136

16.6.6 Predictions using the ggpredict function

Whereas the effects function averages predictions across the different levels of a categorical predictor, producing what are sometimes referred to as marginal effects, the ggpredict function will provide adjusted predictions where all variables except a focal variable remain fixed at their mean, modal, or user-specified values. We first demonstrate this approach for our additive model with voc and year.

ggpredict(mod2)

$voc
# Predicted probabilities of observed

voc | Predicted |     95% CI
----------------------------
  0 |      0.92 | 0.77, 0.98
 10 |      0.89 | 0.73, 0.96
 20 |      0.85 | 0.67, 0.94
 35 |      0.76 | 0.58, 0.88
 55 |      0.60 | 0.42, 0.75
 65 |      0.51 | 0.34, 0.67
 75 |      0.41 | 0.25, 0.59
 95 |      0.25 | 0.12, 0.45

Adjusted for:
* year = 2005

Not all rows are shown in the output. Use `print(..., n = Inf)` to show
  all rows.

$year
# Predicted probabilities of observed

year | Predicted |     95% CI
-----------------------------
2005 |      0.55 | 0.38, 0.71
2006 |      0.44 | 0.28, 0.62
2007 |      0.29 | 0.17, 0.45

Adjusted for:
* voc = 60.00

attr(,"class")
[1] "ggalleffects" "list"        
attr(,"model.name")
[1] "mod2"

As with the ggeffects function, if we specify terms from the model, the function will return a data.frame that can be easily plotted. This approach can be particularly useful when there are interactions between variables as in our mod3 (Figure 16.16).

adjustpredict <- ggpredict(mod3, terms = c("voc", "year"))
plot(adjustpredict, grid = TRUE)  

Figure 16.16: Adjusted prediction plot for the interaction model created using the ggeffects package.

16.7 Logistic regression: Bayesian implementations

Again, an advantage of implementing models in JAGS is that we will be forced to be very clear about the model we are fitting. Specifically, we will have to write down the likelihood with the expression relating \(\text{logit}(p)\) to our predictor variables. Contrast this process with fitting a model using glm where users may not even know that the mean is being modeled on a transformed scale.

In this section, we will fit the logistic regression model containing only voc, leaving the model with year and voc as an in-class exercise. Before we look at JAGS code for fitting this model, it is helpful to give some thought to priors for our regression parameters. It turns out that specifying priors can be a bit tricky. We can specify priors that are vague (meaning they take on a wide range of values, all equally likely) on the logit scale, but this may then imply something very specific when viewed on the \(p\) scale. Consider, for example, the model below, where \(p\) is constant and we specify our prior on the logit scale:

\[Y_i \sim \text{Bernoulli}(p)\] \[\text{logit}(p) = \beta_0\] \[\beta_0 \sim N(0,10^2)\]

It turns out (see Figure 16.17) that this prior is not at all vague when viewed on the \(p\) scale. In particular, this prior suggests that \(p\) is extremely likely to be very near 0 or 1 and unlikely to take on any value in between these two extremes.

par(mfrow=c(1,2))
beta0<-rnorm(10000,0,100)
p<-plogis(beta0)
hist(beta0, xlab=expression(beta[0]), 
     main=expression(paste("Prior distribution for ", beta[0])), 
     col="gray")
hist(p, xlab="p", main="Prior distribution for p", col="gray")

Figure 16.17: A N(0,100) prior distribution for logit(p) results in a non-vague prior on the p scale.

If the goal is to achieve a near uniform distribution for \(p\), it turns out that a \(N(0, \sqrt{3})\) distribution is a much better option (Figure 16.18):

par(mfrow=c(1,2))
beta0<-rnorm(10000, 0, sqrt(3))
p<-plogis(beta0)
hist(beta0, xlab=expression(beta[0]), 
     main=expression(paste("Prior distribution for ", beta[0])), 
     col="gray")
hist(p, xlab="p", main="Prior distribution for p", col="gray")

Figure 16.18: A \(N(0, \sqrt{3})\) distribution for the prior on the logit scale, resulting in a near uniform prior distribution on the \(p\) scale.

Establishing recommendations for default priors is a high priority and active research area within the Bayesian community (see discussion here: https://github.com/stan-dev/stan/wiki/Prior-Choice-Recommendations). For logistic regression models, Gelman et al. (2008) recommended:

1. Scaling continuous predictors so they have mean 0 and sd = 0.5.
2. Using a Cauchy prior, with precision parameter = \(\frac{1}{2.5^2}= 0.16\); this distribution is equivalent to a Student-t distribution with 1 degree of freedom and can be specified in JAGS as: dt(0, pow(2.5,-2), 1).

Both \(t\)- and Normal distributions assume most effect sizes are near 0, but the \(t\)-distribution allows for the possibility of more extreme values since a t-distribution has wider tails than a Normal distribution (Figure 16.19)².

library(LaplacesDemon)
curve(dnorm(x, mean=0, sd=2.5), from=-8, to=8, ylab="Density")
curve(dstp(x, mu=0, tau=1/2.5^2, n=1), from=-8, to=8, add=TRUE, lty=2)
legend(2, 0.15, c("Normal", "t"), lty=c(1,2), bty="n")

Figure 16.19: Comparison of Normal(0, 2.5\(^2\)) (solid curve) and Student-t priors (dashed curve) for logistic regression models.

In general, we may seek a non-informative prior, which means that we want our answers to be determined primarily by the data and likelihood and not the prior. On the other hand, an advantage of a Bayesian approach is that we can potentially take advantage of previous knowledge and data when this information exists and we want it to influence our results. I.e., there may be times when using an informative prior can be beneficial. Furthermore, many would argue for weakly informative priors that “regularize” or shrink parameters towards 0 (e.g., McElreath 2020). This approach is often used to improve predictive performance, particularly in cases where one is faced with having too many explanatory variables relative to one’s sample size (Section 8.7).

16.7.1 Fitting the Bayesian logistic regression model to moose sightability data

Below, we use Gelman’s suggested prior when analyzing the moose data in JAGS:

lrmod<-function(){
  
  # Priors
  # Note: Gelman recommends
  # - scaling continuous predictors so they have mean 0 and sd = 0.5
  # - using a non-informative Cauchy prior dt(0, pow(2.5,-2), 1) 
  # see arxiv.org/pdf/0901.4011.pdf  
  alpha ~ dt(0, pow(2.5, -2), 1)
  beta ~ dt(0, pow(2.5, -2), 1)
  
  # Likelihood
  for(i in 1:n){
    observed[i] ~ dbin(p[i], 1)
    logitp[i] <- alpha + beta * voc[i]
    p[i] <- exp(logitp[i]) / (1 + exp(logitp[i]))
  
    # GOF test
    presi[i] <- (observed[i] - p[i]) / sqrt(p[i] * (1 - p[i]))
    obs.new[i] ~ dbin(p[i], 1)
    presi.new[i] <- (obs.new[i] - p[i]) / sqrt(p[i] * (1 - p[i]))
    D[i] <- pow(presi[i], 2)
    D.new[i] <- pow(presi.new[i], 2)
  }
  fit <- sum(D[])
  fit.new <- sum(D.new[])
}


# Bundle data
voc <- (exp.m$voc - mean(exp.m$voc)) / (0.5 * sd(exp.m$voc))
jagsdata <- list(observed = exp.m$observed, voc = voc, n = nrow(exp.m))

 
# Parameters to estimate
params <- c("alpha", "beta", "p", "presi", "fit", "fit.new")

# MCMC settings
nc <- 3
ni <- 3000
nb <- 1000
nt <- 2

out.p <- jags.parallel(data = jagsdata, parameters.to.save = params, 
                      model.file = lrmod, n.thin= 2, n.chains = 3, 
                      n.burnin = 1000, n.iter = 3000)

#Goodness-of-fit test
fitstats <- MCMCpstr(out.p, params = c("fit", "fit.new"), type = "chains") 
T.extreme <- fitstats$fit.new >= fitstats$fit
(p.val <- mean(T.extreme))

[1] 0.4546667

Looking at the goodness-of-fit test (above), we again fail to reject the null hypothesis that our data are consisten with the assumed model. Below, we compare estimates of coefficients and 95% credible intervals to those obtained usin glm with scaled voc:

MCMCsummary(out.p, params = c("alpha", "beta"), round = 3)

        mean    sd   2.5%    50%  97.5% Rhat n.eff
alpha -0.103 0.203 -0.487 -0.106  0.294    1  3068
beta  -0.494 0.108 -0.708 -0.491 -0.286    1  3000

exp.m$voc.scaled.gelman <- voc # scaled version
mod1b <- glm(exp.m$observed ~ voc.scaled.gelman, family = binomial(),
      data = exp.m)
cbind(coef(mod1b), confint(mod1b))

Waiting for profiling to be done...

                                  2.5 %     97.5 %
(Intercept)       -0.1045001 -0.4980208  0.2864257
voc.scaled.gelman -0.4870714 -0.7114791 -0.2835381

What if we had naively used extremely vague priors for our regression parameters? We can compare the results using the MCMCplot function in the MCMCvis package (Figure 16.20).

lrmodv<-function(){
  
  alpha~dnorm(0, 0.0001)
  beta~dnorm(0, 0.0001)
  
  # Likelihood
  for(i in 1:n){
    observed[i]~dbin(p[i],1)
    logitp[i]<-alpha+beta*voc[i]
    p[i]<-exp(logitp[i])/(1+exp(logitp[i]))
  }
}

params <- c("alpha", "beta")
out.p.vague <- jags.parallel(data = jagsdata, parameters.to.save = params, 
                             model.file = lrmodv, n.thin= 2, n.chains = 3, 
                             n.burnin = 1000, n.iter = 3000)

MCMCplot(object = out.p, object2=out.p.vague, params=c("alpha", "beta"), 
         offset=0.1, main='Posterior Distributions')

Figure 16.20: Comparison of logistic regression models fit using JAGS with different prior distributions for the regression parameters. Plot constructed with the MCMCplot function in the MCMCvis package.

In this case, the priors make little difference to our end results, but that may not always be the case.

16.8 Aside: Logistic regression with multiple trials

If we have multiple observations for each unique set of predictor variables, then we can write the model as:

\[Y_i | X_i \sim Binomial(n_i, p_i)\]

\[logit(p_i) = \log\left(\frac{p_i}{1-p_i}\right) = \beta_0 + \beta_1X_{1,i}+\ldots \beta_kX_{k,i}\]

This formulation can provide significant increases in speed when fitting large data sets (see e.g., Iannarilli et al. 2019). The glm function allows us to fit a logistic regression model to grouped data if we specify the number of trials and the number of successes. We will demonstrate the approach using a famous data set from Bliss (1935), which contains the number of adult flour beetles killed after 5 hours of exposure to gaseous carbon disulfide at various concentrations. The data are contained in a number of different R packages, including the glmx package. We access the data using:

library(glmx)
data("BeetleMortality")
BeetleMortality

    dose died  n
1 1.6907    6 59
2 1.7242   13 60
3 1.7552   18 62
4 1.7842   28 56
5 1.8113   52 63
6 1.8369   53 59
7 1.8610   61 62
8 1.8839   60 60

Let \(Y_i\) be the number of individuals that died and \(n_i\) be the number of beetles exposed to each dosage level. We will assume:

\[Y_i | Dosage_i \sim Binomial(n_i, p_i)\]

\[logit(p_i) = \log\left(\frac{p_i}{1-p_i}\right) = \beta_0 + \beta_1 Dosage_i\]

We can fit the model using:

lrdose <- glm(cbind(died, n - died) ~ dose, data = BeetleMortality, family = binomial())
summary(lrdose)

Call:
glm(formula = cbind(died, n - died) ~ dose, family = binomial(), 
    data = BeetleMortality)

Coefficients:
            Estimate Std. Error z value Pr(>|z|)    
(Intercept)  -60.717      5.181  -11.72   <2e-16 ***
dose          34.270      2.912   11.77   <2e-16 ***
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for binomial family taken to be 1)

    Null deviance: 284.202  on 7  degrees of freedom
Residual deviance:  11.232  on 6  degrees of freedom
AIC: 41.43

Number of Fisher Scoring iterations: 4

To demonstrate that we get the same result if we fit a model to data containing a separate record for each observation, we create a “long format” data set below:

BeetleLong <- NULL
uid <- unique(BeetleMortality$dose)
for(i in seq_along(uid)){
  tempdat <- BeetleMortality[i,]
  BeetleLong <- rbind(BeetleLong, 
                      data.frame(died = c(rep(1, tempdat$died), rep(0, tempdat$n- tempdat$died)),
                                 dose = rep(tempdat$dose, tempdat$n)))
}
head(BeetleLong)

  died   dose
1    1 1.6907
2    1 1.6907
3    1 1.6907
4    1 1.6907
5    1 1.6907
6    1 1.6907

#Show we get the same group summaries as the original data set
BeetleLong %>% group_by(dose) %>%
  dplyr::summarize(died = sum(died), trials = n())

# A tibble: 8 × 3
   dose  died trials
  <dbl> <dbl>  <int>
1  1.69     6     59
2  1.72    13     60
3  1.76    18     62
4  1.78    28     56
5  1.81    52     63
6  1.84    53     59
7  1.86    61     62
8  1.88    60     60

We then fit the same regression model to the set of Bernoulli trials showing that we get the same result:

lrdose2 <- glm(died ~ dose, data = BeetleLong, family = binomial())
summary(lrdose2)

Call:
glm(formula = died ~ dose, family = binomial(), data = BeetleLong)

Coefficients:
            Estimate Std. Error z value Pr(>|z|)    
(Intercept)  -60.717      5.181  -11.72   <2e-16 ***
dose          34.270      2.912   11.77   <2e-16 ***
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for binomial family taken to be 1)

    Null deviance: 645.44  on 480  degrees of freedom
Residual deviance: 372.47  on 479  degrees of freedom
AIC: 376.47

Number of Fisher Scoring iterations: 5

16.9 Aside: Complete separation

Occasionally, when fitting a logistic regression model, you may encounter a warning message that the glm fitting algorithm “did not converge” or that “fitted probabilities numerically 0 or 1 occurred.” This is indicative of a problem referred to as complete separation – in which a predictor variable or set of predictor variables is able to fully discriminate between the 0’s and 1’s.

To demonstrate, we will use an example developed by Jack Weiss using data from Piegorsch and Bailer (2005) collected to evaluate water quality and potential contamination by an industrial solvent trichloroethylene (TCE). The data are included in the Data4Ecologists package and can be accessed using:

library(Data4Ecologists)

Attaching package: 'Data4Ecologists'

The following object is masked from 'package:ggeffects':

    fish

data(wells)

We will build a logistic regression model to describe the probability that a well will be contaminated with TCE as a function of the surrounding land use category (land.use) and whether or not sewers were used in the area surrounding the well (sewer). Each row in the data set contains a unique set of covariates, with y quantifying the number of wells contaminated with TSE and n giving the total number of wells with the same land.use and sewer covariates. Thus, we model the data using glm with a cbind(successes, failures) syntax as described in Section 16.8:

lr1 <- glm(cbind(y, n - y) ~ land.use + sewer, data = wells, family = binomial())
summary(lr1)

Call:
glm(formula = cbind(y, n - y) ~ land.use + sewer, family = binomial(), 
    data = wells)

Coefficients:
               Estimate Std. Error z value Pr(>|z|)    
(Intercept)     -3.6568     0.7376  -4.957 7.14e-07 ***
land.usecomm     1.8676     0.8044   2.322  0.02025 *  
land.useindus    2.2070     0.8053   2.741  0.00613 ** 
land.useinst     0.7584     0.8395   0.903  0.36629    
land.userecr     0.6676     0.8435   0.791  0.42870    
land.useresH     1.7316     0.7784   2.225  0.02611 *  
land.useresL     0.6663     1.0501   0.635  0.52572    
land.useresM     1.0212     0.7809   1.308  0.19099    
land.usetrans    0.7933     0.8360   0.949  0.34267    
land.useundev  -18.3414  3033.9308  -0.006  0.99518    
seweryes         1.5980     0.2955   5.407 6.41e-08 ***
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for binomial family taken to be 1)

    Null deviance: 146.956  on 19  degrees of freedom
Residual deviance:  15.201  on  9  degrees of freedom
AIC: 82.476

Number of Fisher Scoring iterations: 17

Although we didn’t receive a warning in this case, we see the symptoms of complete separation if we inspect the model coefficients and their SEs; namely the coefficient for land.useundev is extremely large in absolute value (-18.34) and its SE is also large (3034).

Think-Pair-Share: Estimate the probability that a well placed in undeveloped land without sewers has TSE contamination. What do you think this indicates about the underlying data?

We can estimate the probability that a well placed in undeveloped land has TSE contamination by adding the intercept and the coefficient for land.useundev and then taking the inverse logit transformation:

betas.lr1 <- coef(lr1)
plogis(betas.lr1[1] + betas.lr1[length(betas.lr1)-1])

 (Intercept) 
2.794265e-10 

We see that this probability is extremely small. Let’s look at the observations broken down by land use category:

wells %>% mutate(nocontam = n-y) %>% group_by(land.use) %>% 
  dplyr::summarize(contam = sum(y), noncontam = sum(nocontam))

# A tibble: 10 × 3
   land.use contam noncontam
   <chr>     <int>     <int>
 1 agri          2        53
 2 comm         20        29
 3 indus        20        25
 4 inst          8        46
 5 recr          7        57
 6 resH         34        59
 7 resL          2        24
 8 resM         17       112
 9 trans         8        51
10 undev         0        76

We see that there are no wells in undeveloped areas that were contaminated. Thus, the smaller the coefficient for land.useundev the better – essentially, the numerical optimizer keeps moving towards \(-\infty\) but at some point the likelihood becomes extremely flat (e.g., consider that our current estimate already equates to a probability on the order fo \(1^{-10}\)). Also, recall that flat likelihoods result in Hessians that are near 0, and as a result, large SEs (see Section 10.6).

There are several different approaches that we might take to deal with this problem. One simple solution would be to group land use categories so that we no longer have complete separation. Another popular approach is to use penalized likelihood or Bayesian approaches (Firth 1993; Fijorek and Sokolowski 2012). Let’s consider a Bayesian model with \(N(\mu = 0, \sigma^2 = 3)\) priors:

lrmod<-function(){
  
  # Priors
  for(i in 1:nlanduse){
    beta.landuse[i] ~ dnorm(0, 1/3)
  }
  beta.sewer ~ dnorm(0, 1/3)
  # Likelihood
  for(i in 1:nobs){
    y[i]~dbin(p[i], n[i])
    logit(p[i]) <-beta.landuse[landuse[i]] + beta.sewer * sewer[i]
  }
}


# Bundle data
jags.data <- list(y = wells$y, 
                  landuse = as.numeric(as.factor(wells$land.use)), 
                  sewer = as.numeric(as.factor(wells$sewer)),
                  n = wells$n, nobs = nrow(wells),
                  nlanduse = length(unique(wells$land.use))) 

 
# Parameters to estimate
params <- c("beta.landuse", "beta.sewer")

# MCMC settings
nc <- 3
ni <- 3000
nb <- 1000
nt <- 2

lr.bayes <- jags.parallel(data = jags.data, parameters.to.save = params,
                       model.file = lrmod, n.thin = 1, n.chains = 3, 
                       n.burnin = 1000, n.iter = 5000) 

Let’s look to make sure everything converged and inspect the SE’s of the different coefficients:

MCMCvis::MCMCsummary(lr.bayes)

                       mean        sd       2.5%        50%       97.5% Rhat
beta.landuse[1]  -3.5816658 0.6176467 -4.9347325 -3.5403297  -2.4724330 1.02
beta.landuse[2]  -1.4576318 0.4655273 -2.3580142 -1.4581147  -0.5485151 1.00
beta.landuse[3]  -1.2347589 0.4630749 -2.1602480 -1.2348759  -0.3467499 1.00
beta.landuse[4]  -2.6557703 0.4907499 -3.6626855 -2.6414482  -1.7253137 1.02
beta.landuse[5]  -2.9142162 0.4867960 -3.9294930 -2.9049714  -2.0013045 1.00
beta.landuse[6]  -1.6369983 0.4255751 -2.4760714 -1.6287131  -0.8162675 1.00
beta.landuse[7]  -2.9165556 0.6427926 -4.2475171 -2.8842078  -1.7498260 1.00
beta.landuse[8]  -2.6806829 0.3799699 -3.4104566 -2.6851236  -1.9373743 1.00
beta.landuse[9]  -2.6881298 0.4667913 -3.6359707 -2.6831948  -1.7882780 1.00
beta.landuse[10] -4.8821682 0.8343893 -6.7384216 -4.8025198  -3.5205098 1.04
beta.sewer        0.6033508 0.2033223  0.2082786  0.6019894   0.9999361 1.00
deviance         86.2354926 7.0437185 74.1456128 85.6594947 101.6587751 1.00
                 n.eff
beta.landuse[1]    371
beta.landuse[2]   1445
beta.landuse[3]   1515
beta.landuse[4]    775
beta.landuse[5]    590
beta.landuse[6]   1552
beta.landuse[7]    577
beta.landuse[8]    901
beta.landuse[9]    850
beta.landuse[10]   154
beta.sewer        1281
deviance          1079

The last landuse coefficient is the one for undeveloped. We see that the N(0, 3) prior helped to stabilize the posterior distribution for this coefficient. We can estimate the probability of a well in an undeveloped area without sewers being contaminated along with a 95% credible interval for this probability using:

# Estimate
MCMCvis::MCMCpstr(lr.bayes, params = "beta.landuse[10]", ISB = FALSE, 
                  func = function(x){mean(plogis(x))})

$`beta.landuse[10]`
[1] 0.01001391

# 95% CI
MCMCvis::MCMCpstr(lr.bayes, params = "beta.landuse[10]", ISB = FALSE, 
                  func = function(x){quantile(plogis(x), probs = c(0.025, 0.975))})

$`beta.landuse[10]`
                        2.5%      97.5%
beta.landuse[10] 0.001183114 0.02873426

The estimate is still very small, but non-zero. And, we are able to report an estimate of uncertainty to go with it.

The logistf package also provides a penalized likelihood approach developed by Firth (1993), which is equivalent to Bayesian logistic regression with a Jeffreys prior. The logistf function requires each observation to be binary (i.e., a Bernoulli response). Thus, we create a “long version” of our data set below.

library(logistf)
WellsLong <- NULL
for(i in 1:nrow(wells)){
  tempdat <- wells[i,]
  WellsLong <- rbind(WellsLong, 
                      data.frame(contam = c(rep(1, tempdat$y), rep(0, tempdat$n- tempdat$y)),
                                 land.use = rep(tempdat$land.use, tempdat$n), 
                                 sewer = rep(tempdat$sewer, tempdat$n)))
}

Then, we fit the model using means coding so that we can easily compare our results to the Bayesian approach:

lrfirth <- logistf(contam ~ land.use + sewer -1, data = WellsLong, family=binomial())
summary(lrfirth)

logistf(formula = contam ~ land.use + sewer - 1, data = WellsLong, 
    family = binomial())

Model fitted by Penalized ML
Coefficients:
                   coef  se(coef) lower 0.95 upper 0.95    Chisq            p
land.useagri  -3.424344 0.6617365  -5.025055 -2.3136352 68.76325 1.110223e-16
land.usecomm  -1.741409 0.3939727  -2.544436 -0.9788752 20.92229 4.782972e-06
land.useindus -1.409143 0.3872128  -2.200166 -0.6614146 14.05506 1.775357e-04
land.useinst  -2.811149 0.4483773  -3.760190 -1.9761494 56.48525 5.662137e-14
land.userecr  -2.895559 0.4450532  -3.853023 -2.0799366 68.76325 1.110223e-16
land.useresH  -1.878656 0.3381481  -2.574947 -1.2278191 35.33950 2.769582e-09
land.useresL  -2.770159 0.6920825  -4.415058 -1.5807259 28.47004 9.515975e-08
land.useresM  -2.580059 0.3157102  -3.244995 -1.9922454      Inf 0.000000e+00
land.usetrans -2.777363 0.4372769  -3.707734 -1.9676855 60.79674 6.328271e-15
land.useundev -5.632506 1.4246979 -10.478750 -3.6571844      Inf 0.000000e+00
seweryes       1.555010 0.2842178   1.004490  2.1479905 33.46428 7.258474e-09
              method
land.useagri       2
land.usecomm       2
land.useindus      2
land.useinst       2
land.userecr       2
land.useresH       2
land.useresL       2
land.useresM       2
land.usetrans      2
land.useundev      2
seweryes           2

Method: 1-Wald, 2-Profile penalized log-likelihood, 3-None

Likelihood ratio test=347.4569 on 11 df, p=0, n=650
Wald test = 168.1994 on 11 df, p = 0

We see again that the estimate of the coefficient for the undeveloped category is shrunk back towards 0, but not as much as in our Bayesian model using the N(0, 3) prior.

16.10 References

ArchMiller, Althea A, Robert M Dorazio, Katherine St Clair, and John Fieberg. 2018. “Time Series Sightability Modeling of Animal Populations.” PloS One 13 (1).

Bliss, Chester Ittner. 1935. “The Calculation of the Dosage-Mortality Curve.” Annals of Applied Biology 22 (1): 134–67.

Fieberg, John. 2012. “Estimating Population Abundance Using Sightability Models: R SightabilityModel Package.” Journal of Statistical Software 51 (9): 1–20.

Fieberg, John, Michael Alexander, Scarlett Tse, and Katie St. Clair. 2013. “Abundance Estimation with Sightability Data: A Bayesian Data Augmentation Approach.” Methods in Ecology and Evolution 4 (9): 854–64.

Fijorek, Kamil, and Andrzej Sokolowski. 2012. “Separation-Resistant and Bias-Reduced Logistic Regression: Statistica Macro.” Journal of Statistical Software 47: 1–12.

Firth, David. 1993. “Bias Reduction of Maximum Likelihood Estimates.” Biometrika 80 (1): 27–38.

Fox, John, and Sanford Weisberg. 2018. “Visualizing Fit and Lack of Fit in Complex Regression Models with Predictor Effect Plots and Partial Residuals.” Journal of Statistical Software 87 (9): 1–27. https://doi.org/10.18637/jss.v087.i09.

———. 2019. An R Companion to Applied Regression. Third. Thousand Oaks CA: Sage. https://socialsciences.mcmaster.ca/jfox/Books/Companion/.

Gelman, Andrew, and Jennifer Hill. 2006. Data Analysis Using Regression and Multilevel/Hierarchical Models. Cambridge university press.

Gelman, Andrew, Aleks Jakulin, Maria Grazia Pittau, Yu-Sung Su, et al. 2008. “A Weakly Informative Default Prior Distribution for Logistic and Other Regression Models.” The Annals of Applied Statistics 2 (4): 1360–83.

Giudice, John H, John Fieberg, and Mark S Lenarz. 2012. “Spending Degrees of Freedom in a Poor Economy: A Case Study of Building a Sightability Model for Moose in Northeastern Minnesota.” The Journal of Wildlife Management 76 (1): 75–87.

Hosmer Jr, David W, Stanley Lemeshow, and Rodney X Sturdivant. 2013. Applied Logistic Regression. Vol. 398. John Wiley & Sons.

Iannarilli, Fabiola, Todd W Arnold, John Erb, and John Fieberg. 2019. “Using Lorelograms to Measure and Model Correlation in Binary Data: Applications to Ecological Studies.” Methods in Ecology and Evolution 10 (12): 2153–62.

Lele, Subhash R., Jonah L. Keim, and Peter Solymos. 2019. ResourceSelection: Resource Selection (Probability) Functions for Use-Availability Data. https://CRAN.R-project.org/package=ResourceSelection.

Lüdecke, Daniel. 2018. “Ggeffects: Tidy Data Frames of Marginal Effects from Regression Models.” Journal of Open Source Software 3 (26): 772. https://doi.org/10.21105/joss.00772.

Lüdecke, Daniel, Mattan S. Ben-Shachar, Indrajeet Patil, Philip Waggoner, and Dominique Makowski. 2021. “performance: An R Package for Assessment, Comparison and Testing of Statistical Models.” Journal of Open Source Software 6 (60): 3139. https://doi.org/10.21105/joss.03139.

McElreath, Richard. 2020. Statistical Rethinking: A Bayesian Course with Examples in r and Stan. CRC press.

Piegorsch, Walter W, and A John Bailer. 2005. Analyzing Environmental Data. John Wiley & Sons.

Statisticat, and LLC. 2021. LaplacesDemon: Complete Environment for Bayesian Inference. Bayesian-Inference.com. https://web.archive.org/web/20150206004624/http://www.bayesian-inference.com/software.

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1. The distribution of the \(\chi^2\) goodness-of-fit test statistic will follow a \(\chi^2\) distribution when sample sizes are large and the null hypothesis is true.

2. Here we use the dstp function in the LaplacesDemon package (Statisticat and LLC. 2021) since it is parameterized in the same way as the dt function in JAGS